The magazine contained articles about Commodore 8-bit home computers and peripherals, as well as reviews on available software packages for the computers. In addition, every issue featured several type-in programs written in BASIC and/or machine language. The magazine's name came from the BASIC command "RUN", which started execution of the computer's program, presumably typed in from the magazine.
The demise of the magazine was due to the public's dwindling interest in 8-bit machines as the computer world evolved to 16-bit and standardized on the IBM PC compatible platform for both business and home use. The front cover was originally accented by a logotype reading "RUN", with each letter placed on a key button resembling those used on the C-64. In June 1987 the keys were removed and the font became italicized with rounded letters.